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Gene-phages were monstrous weapons created during Old Night, that were later used heavily by the First Legion during the Unification Wars and Great Crusade.[1]

While such weapons as the Gene-phages and Rad Waves were available for the Space Marine Legions to use, only the First Legion made common use of them. And even they only unleashed these weapons of Old Night to wipe clean the nests of enemies, the First Legion deemed too terrible to be faced in open battle.[1]