Khalophis was a Captain of the Thousand Sons during the Great Crusade and Horus Heresy. Commanding the 6th Fellowship, he oversaw the Pyrae Cult. During the Burning of Prospero Khalophis sent his consciousness into the inert Warlord Class Titan Canis Vertex, taking control of the machine. With his soul inside the Titan Khalophis wrought destruction on the Space Wolves and their allies, nearly turning the tide of the battle. However the Canis Vertex was caught in the psychic explosion caused by the death of 7th Fellowship captain Phael Toron, causing the Titan to explode and annihilating Khalophis' soul.