Ogryn Berserkers are Ogryns corrupted by Khornate Chaos Warbands, driven insane by bloodlust and evolving into ferocious and bloodthirsty beasts. Similar to Khorne Berzerkers, these creatures were lobotomized and injected with a powerful combat drug known as "Slaught". Once Slaught is introduced into the bloodstream, the Ogryn becomes a raging psychopath. The downside of this treatment is the drug-fueled rampage cannot be sustained by the Ogryn's body and complete organ failure is an inevitable result of prolonged combat by Ogryn Berserkers.
Ogryn Berserkers are known to be surgically modified by their masters in order to create a more potent killing machine. These include surgically removing limbs and replacing them with blades, buzz-saws, or other vicious weaponry.