The subordinate to Fabricator-General Kelbor-Hal, Kane was loyal to Terra and the Emperor and as a result refused to submit to Hal's new Dark Mechanicum that was pledging its allegiance to Warmaster Horus. Controlling a vast Forge Complex, Kane became one of the key leaders of the resistance to the Dark Mechanicum in the Schism of Mars, the devastating civil war that ripped through Mars. In the end, when it became clear that the traitor forces would emerge victorious, loyalist forces, including Kane, evacuated the planet with the aid of Captain Sigismund of the Imperial Fists.
Following the exile of the loyalist Mechanicum to Terra, Kane was named the new Fabricator-General of Mars but ruled in name only. Embittered, he became increasingly inhuman in his augmentations. By the late Heresy, he had few human features left and moved by tank treads in place of his legs. He had grown disdainful of many of his loyalist Mechanicum followers, casually shooting a thrall that attempted to pray to him while he was busy. During the War Within the Webway Kane was a loyalist commander but sought to work with Arkhan Land to find a way to reach Mars through the Webway.
Kane's status during the Heresy was unstable. The Mechanicum considered the division of the Mechanicum with Hal and Kane both claiming the title of Fabricator General an unresolved equation, known as the "binary succession". In an attempt to resolve this, Ambassador Vethorel, Fabricator General Kane's representative on the Council of Terra, proposed to resolve this by the creation of a new Adeptus, the Adeptus Mechanicus. Despite the Mechanicum's concerns for their independence and the council's fears of a Martian power-grab, the resolution passed after the Collegia Titanica threatened to abandon the Solar War and the Imperator Titan Magnificum Incendius of the Legio Ignatum marched on the Great Chamber of the Senatorum Imperialis.
During the Siege of Terra Kane relocated his library deep under the Imperial Palace. After finding out from Esha Ani Mohana that Horus was wounded during the Battle of Beta-Garmon he met with Sanguinius and relayed the information. Dorn describes Kane as loyal but proud by the Siege. During the final stages of the Siege of Terra, Kane wept with his adepts at the loss of their precious God-Engines.
- 1: Dark Adeptus (Novel), Chapter 2
- 2: Mechanicum (Novel), Chapter 3.04
- 3: Master of Mankind (Novel), Chapter 7
- 4: The Binary Succession (Audio Drama)
- 5: The Lost and the Damned (Novel), Chapter 8
- 6: The End and the Death: Volume I (Novel) - 1:xxiii